Asymmetric Synthesis and Bio -Organic Chemistry MCQ Unit-II M.Sc. Chemistry Sem.III

M. Sc. Organic Chemistry Sem.III

CHEO – 315

Asymmetric Synthesis and Bio - Organic Chemistry

Third Semester

UNIT - II

Enzyme Chemistry Nomenclature, Classification and Extraction of enzymes, Structural outlines of enzymes (proteins); Introduction to catalysis and enzymes; Multifunctional catalysis, Intramolecular catalysis, Molecular asymmetry and prochirality, Mechanism of enzyme action, Factors responsible for enzyme specificity, Enzyme activity and kinetics (Michaelis Menten and Lineweaver - Burk plots), Enzyme Inhibitions (Reversible and Irreversible), Applications of a - Chymotrypsin, Ribonuclease, lysozyme and Carbopeptidase A. Enzymes in synthetic organic chemistry. [Additions, eliminations, substitutions, condensations, cyclocondensations, oxidations, reductions and rearrangement reactions are to be covered]

Multiple Choice questions:

1. The enzyme that transfer hydrogen or oxygen atoms from one substrate to other substrate is called as
a) Oxidoreductases
b) Transferases
c) Hydrolases
d) All of these

2. Enzymes that catalyze group transfer reactions called as
a) Oxidoreductases
b) Transferases
c) Hydrolases
d) All of these

3. Enzymes that catalyze hydrolytic reactions called as….
a) Oxidoreductases
b) Transferases
c) Hydrolases
d) All of these

4. Removal of functional group from substrate carried out by enzyme
a) Oxidoreductases
b) Transferases
c) Hydrolases
d) All of these

5. Recemization and isomerization reaction carried out by
a) Ligases
b) Lyses
c) Isomerases
d) All of the above

6. Protein extraction carried out by the method
a) Gel chromatography
b) Column chromatography
c) Ion exchange chromatography
d) All of these

7. Equilibrium in enzyme substrate was given in
a) Briggs and Haldane approach
b) Michaelis-Menten approach
c) Both a and b
d) None of these

8. Steady state assumption was given in…
a) Briggs and Haldane approach
b) Michaelis-Menten approach
c) Both a and b
d) None of these

9. Catalytic properties of enzymes influenced by
a) Temperature
b) Pressure
c) PH value
d) All of above

10. What is optimum PH of enzymatic reaction?
a) 6
b) 7
c) 8
d) 14

11. What type of interaction occur between each -COOH group of substrate molecule and functional group of active site in an enzyme
a) Hydrogen bonding
b) Ionic bonding
c) Dispersion Force
d) All of these

12. What type of interaction occur between each NH3+ group of substrate molecule and functional group of active site in an enzyme
a) Hydrogen bonding
b) Ionic bonding
c) Dispersion Force
d) All of these

13. What type of interaction occur between each CH(CH3)2 group of substrate molecule and functional group of active site in an enzyme
a) Hydrogen bonding
b) Ionic bonding
c) Dispersion Force
d) All of these

14. Prominent attractive force that stabilizes formation of secondary structure of proteins?
a) Hydrogen bonding
b) Ionic interaction
c) Vander wall forces
d) London forces of attraction

15. Concentration of substrate increases it…..
a) Increases rate of reaction
b) Decreases rate of reaction
c) Neither decrease nor increase rate of reaction
d) Decreases rate of reaction and increase product formation

16. Enzyme becomes inactive at ----
a) Very low temperature
b) Room temperature
c) Very high temperature
d) At zero degree Celsius

17. Irreversible inhibitor inactivate enzyme by..
a) Bonding covalently to particular group active site
b) Bonding non covalently to particular group active site
c) Bonding by attractive forces to active site
d) None of these

18. Reversible inhibitor inactivate enzyme by..
a) Bonding covalently to particular group active site
b) Bonding non covalently to particular group active site
c) Bonding by attractive forces to active site
d) None of these

19. Non protein part in enzyme called
a) Cofactor
b) Catalyst
c) Isoenzyme
d) All of these

20. Organic molecules act as a cofactor called as….
a) Coenzyme
b) Bimolecules
c) Organic enzymes
d) All of these

21. Coenzymes are synthesized from
a) Vitamins
b) Minerals
c) Both a and b
d) None of these

22. The enzyme that catalyzes conversion of ethanol to acetaldehyde…
a) Hydrolases
b) Oxidoreductase
c) Lyses
d) Isomerases

23. The enzyme that catalyzes breakdown of glucose-6-phosphate to glucose
a) Hydrolases
b) Oxidoreductase
c) Lyses
d) Isomerases

24. Asymmetric aldol reaction catalyzed by….
a) Ketoreductase
b) Aldo-ketoreductase
c) Aldoreductase
d) Reductase

25. Enzyme catalyzed Mannich reaction carried out by..
a) Acylase
b) Reductase
c) Isomerase
d) Ligases

26. Oxidation of anthracene carried out by enzyme…
a) Laccases
b) Peroxidases
c) Oxidase-peroxidase
d) Cloroperoxidase

27. Sulfoxidation of thioanisole carried out by enzyme….
a) Laccases
b) Peroxidases
c) Oxidase-peroxidase
d) Cloroperoxidase

28.Oxidation of 1, 2 -dihydro naphthalene carried out by enzyme…
a) Laccases
b) Peroxidases
c) Oxidase-peroxidase

d) Cloroperoxidase

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